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KMID : 0371619950110020235
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Journal of Wonkwang Medical Science
1995 Volume.11 No. 2 p.235 ~ p.246
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Correlation between P-glycoprotein, CEA and Established Prognostic factors in Breast Cancer
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Lee Kwang-Man
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Abstract
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P-glycoprotein is a membrane glycoprotein which has been thought to function as a drug efflux pump responsible for multidrug resistance(MDR). It has been detected in various human cancers, and is thought to be related to response to chemotherapy and prognosis. The aim of this study was to investigate the correlation between P-glycoprotein & CEA immunoreactivity and various histologic and immunochemical prognostic variables in primary breast cancer. P-glycoprotein and CEA were detected in formalin-fixed, paraffin embedded tissue from 62 patients with breast carcinoma by immunohistochemical method using monoclonal antibodies, MDR JSB-1(SANBIO) for P-glycoprotein and A5B7(DAKO) for CEA. Immunoreactivities of P-glycoprotein and CEA were correlated with various prognostic variables, eg. stage, axillary nodal status, estrogen & progesterone receptors, p53, and PCNA(proliferating cell nuclear antigen) expression. P-glycoprotein was expressed in 20 out of 53 cases(37.7%), and CEA was expressed in 28 out of 56 cases(50.0%). There was no relationship between P-glycoprotein expression and prognostic factors except PCNA(Pearson’s correlation coefficient r = 0.32, p = 0.022). CEA immunoreactivity was related to stage(r = 0.2847, P = 0.033). p53(r = 0.3413, p = 0.033). PCNA(r = 0.2722, p = 0.044). and P-glycoprotein (r = 0.4175, p = 0.003), but was not related to lymph node or hormone receptors status. These results suggest that tissue CEA expression may have some prognostic value in primary breast cancer. It seems to be needed to analize patients’ survival rate according to CEA immunoreactivity in future study.
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KEYWORD
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